The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia

Article ID	Journal	Published Year	Pages	File Type
5844494	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2014	10 Pages	PDF

Abstract

âº Cytokines are closely related to inflammation and neurogenesis in the brain. âº Neuroinflammation and neurodegeneration play important roles in the pathogenesis of schizophrenia. âº Adjuvant anti-inflammatory treatment for schizophrenia is under investigation. âº Specific inflammatory biomarkers for schizophrenia need to be identified.

Keywords

Th1 IL-8 CATIE MDD COX-1 SVZ Th17 SGZ AMPA Th2 TNF-α receptor 1 IL-10 IL-3 IL-12 NMDA N-methyl-d-aspartate IFN-γ IL-2 gp130 COX-2 Clinical Antipsychotic Trials of Intervention Effectiveness IL-6 IL-4 IDO TNF-R1 NRG-1 TGF-β LIF DISC-1 SNPs mRNA TNF-R2 sIL-2R MAPK PolyI:C messenger RNA Major depressive disorder Disrupted-in-schizophrenia 1 Schizophrenia alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ribonucleic acid RNA kynurenic acid Neuroinflammation Indolamine 2,3-dioxygenase interleukin-12 interleukin-4 Interleukin-8 Interleukin-10 interleukin-6 Interleukin-3 Interleukin-2 Transforming Growth Factor Beta long-term potentiation LTP Neurodegeneration tumor necrosis factor alpha CNS BBB Blood–brain barrier Cytokine central nervous system cyclooxygenase-1 Cyclooxygenase-2 leukemia inhibitory factor TNF-α CSF Cerebrospinal fluid soluble IL-2 receptor subgranular zone subventricular zone HPA Neurogenesis hypothalamus-pituitary-adrenal C-reactive protein CRP mitogen-activated protein kinase Single nucleotide polymorphisms KYNA Interferon gamma glycoprotein 130