Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis

Article ID	Journal	Published Year	Pages	File Type
5844511	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2014	7 Pages	PDF

Abstract

Adjunctive treatment with NSAIDs, particularly celecoxib, can be a promising strategy for patients with depressive disorder. Future studies with a larger sample size and longer study duration are needed to confirm the efficacy and tolerability of NSAIDs for depression.

Keywords

NSAID MADRS IDO DSM-IV IL-1β PRISMA hs-CRP MDD RCT HRSD DSM-IV-TR GENDEP IFN-α LPS IL-6 WMD BDNF STAR*D Randomized controlled trial Randomized controlled trials Preferred Reporting Items for Systematic Reviews and Meta-Analyses Major depressive disorder Depression inflammation interferon-alpha interleukin-6 interleukin-1beta indoleamine 2,3-dioxygenase tumor necrosis factor-alpha Cochrane Central Register of Controlled Trials Sequenced Treatment Alternatives to Relieve Depression CNS World Health Organization central nervous system Non-steroidal anti-inflammatory drug TNF-α brain-derived neurotrophic factors Meta-analysis lipopolysaccharide Central Montgomery–Åsberg Depression Rating Scale Hamilton Rating Scale for Depression Selective serotonin reuptake inhibitor SSRI weighted mean difference high sensitivity C-reactive protein WHO