Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5844640 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2013 | 6 Pages |
Abstract
⺠Imaging of dopamine transporters measures the density of dopamine neuron terminals ⺠Normal loss of dopamine terminals in healthy individuals is about 5% per decade. ⺠Dopamine neuron loss is 15% per decade in antipsychotic-treated schizophrenia ⺠Antipsychotic accumulation in nigral neuromelanin causes loss of dopamine terminals ⺠Dopamine neuron loss may lead to tardive dyskinesia
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Authors
Philip Seeman, Michele Tinazzi,