Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants

Article ID	Journal	Published Year	Pages	File Type
5844656	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2013	12 Pages	PDF

Abstract

âº Oxidative/nitrosative stress may partly contribute to the pathogenesis of depression. âº Antidepressants' effects may be influenced by oxidative/nitrosative stress. âº Oxidative/nitrosative stress pathways may be novel antidepressant targets.

Keywords

TST Nrf2 NAC CAT NOS 5-hydroxytryptamine RNS FST NO synthase GSK3 IDO COX EFE INF-γ 5-HT CREB BDNF DNA N-acetylcysteine ROS Adenosine Triphosphate ATP Forced swimming test tail-suspension test cyclooxygenase Oxidative/nitrosative stress deoxyribonucleic acid Depression interferon-gamma SOD Superoxide dismutase endoplasmic reticulum Antidepressant nuclear factor E2-related factor 2 antioxidant response element Brain-derived neurotrophic factor hypothalamic–pituitary–adrenal axis HPA NAD Nitric oxide NAD, nicotinamide adenine dinucleotide Novel target ARE Catalase glycogen synthase kinase 3 reactive nitrogen species Reactive oxygen species