Different effects of the NMDA receptor antagonists ketamine, MK-801, and memantine on postsynaptic density transcripts and their topography: Role of Homer signaling, and implications for novel antipsychotic and pro-cognitive targets in psychosis

Article ID	Journal	Published Year	Pages	File Type
5844657	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2013	12 Pages	PDF

Abstract

These data may support the view that ketamine, MK-801 and memantine exert divergent effects on PSD transcripts, which may contribute to their partially different behavioral and clinical effects.

Keywords

ACC core of the nucleus accumbens shell of the nucleus accumbens PSD-95 N-methyl-d-aspartate NMDA TdT mGluR5 DEPC hsp70 HOMER1 SSC PSD S.E.M PBS BDNF ROIs EDTA ethylene-diamine-tetra-acetic acid Schizophrenia ANOVA one-way analysis of variance postsynaptic density standard error mean Antipsychotics Dopamine diethylpyrocarbonate Brain-derived neurotrophic factor Phosphate buffered saline Motor cortex insular cortex Somatosensory cortex anterior cingulate cortex Medial agranular cortex Arc Regions Of Interest MAC CORE Shell glutamate

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Life Sciences Neuroscience Biological Psychiatry

Different effects of the NMDA receptor antagonists ketamine, MK-801, and memantine on postsynaptic density transcripts and their topography: Role of Homer signaling, and implications for novel antipsychotic and pro-cognitive targets in psychosis

Authors

Andrea de Bartolomeis, Chiara Sarappa, Elisabetta F. Buonaguro, Federica Marmo, Anna Eramo, Carmine Tomasetti, Felice Iasevoli,