The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients

Article ID	Journal	Published Year	Pages	File Type
5844751	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2013	8 Pages	PDF

Abstract

âº We investigated HIF-1 mRNA in the leukocytes of patients with mood disorder. âº HIF-1 and its target genes mRNA were increased mainly in a state-dependent manner. âº HIF-1 may be associated with the pathophysiology of depression.

Keywords

EPO DSM-IV BNIP3 GDNF HDRS BPD ARNT MDD SNRI PGK1 VPA HIF-1 IGF-2 Cbz PFKFB3 AHR LDHA Lithium BDNF q-PCR aryl hydrocarbon receptor nuclear translocator Major depressive disorder mood disorder bipolar disorder erythropoietin Gene expression Diagnostic and Statistical Manual of Mental Disorders, fourth edition Valproate hypoxia inducible factor-1 Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Insulin-like growth factor-2 Glial cell line-derived neurotrophic factor Brain-derived neurotrophic factor Leukocyte Hamilton Depression Rating Scale selective serotonin reuptake inhibitors SSRI quantitative real-time polymerase chain reaction carbamazepine aryl hydrocarbon receptor

Related Topics

Life Sciences Neuroscience Biological Psychiatry

The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients

Authors

Tomohiko Shibata, Hirotaka Yamagata, Shusaku Uchida, Koji Otsuki, Teruyuki Hobara, Fumihiro Higuchi, Naoko Abe, Yoshifumi Watanabe,