| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5844755 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2013 | 8 Pages |
Abstract
⺠Bipolar mania is associated with an increase in dopaminergic neurotransmission. ⺠Lisdexamfetamine dimesylate is a novel stimulant which enhances dopaminergic tone. ⺠Chronic lisdexamfetamine treatment induced hyperlocomotion in rats. ⺠Lisdexamfetamine treatment increased oxidative stress in areas of the rat brain. ⺠Lithium prevented and reversed lisdexamphetamine-induced hyperlocomotion.
Keywords
lisdexamfetamine dimesylateMDAd-AMPHGCLMPFCLDXMAOGSHTBARSLithiumROSbipolar disorderattention deficit hyperactivity disorderStriatumADHDanalysis of varianceANOVAOxidative stressstandard errors of the meanCNSDopamined-Amphetaminecentral nervous systemprefrontal cortexmalonaldehydeSEMmonoamine oxidaseHippocampusreduced glutathionethiobarbituric acid reactive speciesReactive oxygen species
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Danielle S. Macêdo, David F. de Lucena, Ana Isabelle G. Queiroz, Rafaela C. Cordeiro, MaÃra M. Araújo, Francisca Cléa Sousa, Silvânia M. Vasconcelos, Thomas N. Hyphantis, João Quevedo, Roger S. McIntyre, André F. Carvalho,