Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD

Article ID	Journal	Published Year	Pages	File Type
5844756	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2013	8 Pages	PDF

Abstract

âº PTSD is characterized by reduced lymphocyte GR hormone-binding potential. âº Compensation between GR number and hormone-binding affinity is disturbed in PTSD. âº Resilience to PTSD is associated with increased fractional occupancy of the GR.

Keywords

BDI-II SCID-CV Imax β actin IC50 ECF GAPDH ANCOVA Bmax SPSS PBMCs 50% inhibitory concentration Posttraumatic stress disorder PTSD sodium dodecyl sulfate-polyacrylamide gel electrophoresis SDS-PAGE analysis of covariance analysis of variance ANOVA War trauma equilibrium dissociation constant peripheral blood mononuclear cells enhanced chemifluorescence HPA axis Hypothalamic-pituitary-adrenocortical axis polymerase chain reaction PCR Glyceraldehyde phosphate dehydrogenase glucocorticoid receptor

Related Topics

Life Sciences Neuroscience Biological Psychiatry

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Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD

Authors

Gordana MatiÄ, Danijela VojnoviÄ MilutinoviÄ, Jelena Nestorov, Ivana ElakoviÄ, Sanja ManitaÅ¡eviÄ JovanoviÄ, Tatjana PeriÅ¡iÄ, Jadranka DunÄerski, Svetozar DamjanoviÄ, Goran KneÅ¾eviÄ, Å½eljko Å piriÄ, Eric Vermetten, Danka SaviÄ,