Synaptic plasticity in depression: Molecular, cellular and functional correlates

Article ID	Journal	Published Year	Pages	File Type
5844766	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2013	17 Pages	PDF

Abstract

âº Synaptic form and function are altered by chronic stress and in depression. âº Changes to plasticity are correlated by those to signal transduction pathways. âº Altered synaptic plasticity may correlate neurometabolic deficits. âº Altered synaptic plasticity may underlie altered cognition and emotion.

Keywords

N-methyl-d-aspartic acid receptor AMPAR pKa CREB MPFC CUMS nNOS TrkB NMDAR 5-HT1A PSD-95 mGluR GSK-3 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor SNRI MAOI NRI VDCC SSRE serotonin receptor type 1A iNOS NAC TCA mTOR CIS ERK CRS ACC PI3K BDNF cAMP ECs MAPK MAPK kinase NMDA receptor Cyclic adenosine monophosphate Akt Chronic stress Chronic restraint stress Major depression cAMP response element-binding Electroconvulsive seizure chronic unpredictable mild stress Tricyclic antidepressant inducible nitric oxide synthase neuronal nitric oxide synthase dentate gyrus Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Brain-derived neurotrophic factor anterior cingulate cortex medial prefrontal cortex MEK Selective serotonin reuptake inhibitor noradrenaline reuptake inhibitor monoamine oxidase inhibitor SSRI dopamine receptor type 1 mammalian target of rapamycin Nucleus accumbens postsynaptic density protein 95 protein kinase A protein kinase B mitogen-activated protein kinase Synaptic plasticity Voltage-dependent calcium channel extracellular signal-regulated kinase glycogen synthase kinase-3 Metabotropic glutamate receptor