| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5844861 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2012 | 8 Pages |
Abstract
⺠Aging affects glutamatergic signaling in hippocampus. ⺠Mitochondrial calcium is related with this aged-alteration. ⺠There is a reduction in glutamate responses in hippocampus in aged rats. ⺠Sleep restriction induces increase in calcium signaling in hippocampus of aged rats. ⺠Apoptosis is elevated in aged animals and even more in sleep restricted rats.
Keywords
CSRAMPACA3CA2REMFCCPN-methyl-d-aspartateNMDAcornu ammonis 3α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidcornu ammonis 2Two-way analysis of varianceANOVATerminal deoxynucleotidyl transferase dUTP nick end labelingTUNELrapid eye movementApoptosissleep restrictionchronic sleep restrictionSleep deprivationAgedHippocampuscarbonyl cyanide-p-trifluoromethoxyphenylhydrazoneCalcium
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Luciane de Souza, Soraya S. Smaili, Rodrigo P. Ureshino, Rita Sinigaglia-Coimbra, Monica L. Andersen, Guiomar S. Lopes, Sergio Tufik,