| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5844862 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2012 | 9 Pages |
Abstract
⺠The 2-DMPI agent was demonstrated to be a mixed, reversible and preferential MAO-A inhibitor in the brain of mice. ⺠The 2-DMPI agent presented an antidepressant-like effect without disrupting motor performance. ⺠The 2-DMPI agent decreased serotonin and dopamine turnover in certain brain regions. ⺠The antidepressant-like effect of 2-DMPI is modulated by serotonergic and dopaminergic systems.
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Jardel Gomes Villarinho, Roselei Fachinetto, Francielle de Vargas Pinheiro, Gabriela da Silva Sant'Anna, Pablo Machado, PatrÃcia Andréia Dombrowski, Cláudio da Cunha, Daniela de Almeida Cabrini, Marcos Antônio Pinto Martins, Helio Gauze Bonacorso,