| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5844898 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2012 | 7 Pages |
Abstract
⺠Blonanserin is not a P-gp substrate in both in vitro and in vivo experiments. ⺠Brain distribution of blonanserin is unlikely to be affected by P-gp. ⺠For non P-gp substrate blonanserin, there is no need to worry about P-gp-mediated DDI.
Keywords
B/PMDR1P-gpDDIHBSSSDAEPSHEPESFBSCmax2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acidBlonanserinBSAP-glycoproteinbovine serum albuminI.S.internal standarddrug–drug interactionPositron emission tomographymaximum drug concentrationCNSRisperidonefetal bovine serumcentral nervous systemExtrapyramidal symptomsKnockout miceknockoutwild-typePETmultidrug resistance protein 1
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Authors
Tomoko Inoue, Kenichi Osada, Masaaki Tagawa, Yuriko Ogawa, Toshiaki Haga, Yoshihisa Sogame, Takanori Hashizume, Takashi Watanabe, Atsushi Taguchi, Takashi Katsumata, Masashi Yabuki, Noboru Yamaguchi,