The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, Î²-caryophyllene, in male mice

Article ID	Journal	Published Year	Pages	File Type
5845067	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2012	9 Pages	PDF

Abstract

âº S. odoratissima essential oil (EO) and Î²-caryophyllene has anxiolytic-like effect. âº EO or Î²-caryophyllene does not produce motor impairment. âº EO anxiolytic-like effects were blocked by NAN-190, but not by Flumazenil. - Î²-caryophyllene anxiolytic-like effects were not blocked by NAN-190 or Flumazenil.

Keywords

UFG LDB NAN-190 s.c.CB2 p.o.β-Caryophyllene CB1 i.p.EPM GAD 5-Hydroxytryptamine 1A receptor 5-HT1A receptor elevated plus maze test generalized anxiety disorder standard error of the mean Intraperitoneally CNS subcutaneously central nervous system orally Flumazenil SEM Cannabinoid 1 receptor Cannabinoid 2 receptor

Related Topics

Life Sciences Neuroscience Biological Psychiatry

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The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, Î²-caryophyllene, in male mice

Authors

Pablinny Moreira Galdino, Marcus VinÃcius Mariano Nascimento, Iziara Ferreira Florentino, Roberta Campos Lino, James Oluwagbamigbe Fajemiroye, Beatriz Abdallah Chaibub, José Realino de Paula, Thereza Christina Monteiro de Lima, Elson Alves Costa,