Neuroendocrine control of maternal stress responses and fetal programming by stress in pregnancy

Article ID	Journal	Published Year	Pages	File Type
5845094	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2011	14 Pages	PDF

Abstract

âºKey changes in neuroendocrine systems for a successful pregnancy are reviewed. âºThe impact of early life programming on offspring health and coping is explained. âºPhenomenon of reduced maternal hormonal stress responses in pregnancy is described. âºEvidence for activation of a central inhibitory opioid mechanism by neurosteroids. âºCritical review of mechanisms of fetal programming by maternal stress in pregnancy.

Keywords

parvocellular paraventricular nucleus α-MSH THDOC NTS pPVN tetrahydrodeoxycorticosterone IL-1β CpG ACTH GnRH NPY POMC EPM TIDA mRNA CRH LPS 3α-HSD 3α-hydroxysteroid dehydrogenase CeA γ-aminobutyric acid type A receptor Prenatal stress γ-aminobutyric acid allopregnanolone Urocortin Endogenous opioid Interleukin-1β elevated plus maze messenger ribonucleic acid Cytosine-phosphate-Guanine lipopolysaccharide Hypothalamo-pituitary-adrenal axis HPA Nucleus tractus solitarii central nucleus of the amygdala adrenocorticotrophic hormone gonadotropin releasing hormone α-Melanocyte stimulating hormone hypothalamo-pituitary-adrenal PNS GABAA GABA Mineralocorticoid receptor Progesterone receptor glucocorticoid receptor Neuropeptide Y