Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

Article ID	Journal	Published Year	Pages	File Type
5845104	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2011	7 Pages	PDF

Abstract

âº In this study we search oxidative parameters in fifty major depressive disorder patients. âº Effects of antidepressant treatment are detected during a 24-week follow-up period. âº Oxidative stress seems to have a role in major depressive disorder. âº Oxidative stress is partly improved by long-term antidepressant treatment.

Keywords

MDD TAOC MDA HARS oxLDL VLDL HDRS DSM-IV CMS PON1 RBC HDL CVS CAT GSH-Px Oxidized LDL ROS Antioxidants Major depressive disorder chronic mild stress Polyunsaturated fatty acid PUFA cardiovascular disease Oxidative stress Diagnostic and Statistical Manual of Mental Disorders, fourth edition CVD SOD Superoxide dismutase body mass index BMI Antidepressant coefficients of variation Total antioxidative capacity high density lipoprotein very low density lipoprotein low density lipoprotein LDL malondialdehyde Cu,Zn-SOD Hamilton anxiety rating scale Hamilton Depression Rating Scale Paraoxonase Catalase red blood cell glutathione reductase glutathione peroxidase Reactive oxygen species