Blockade of the NMDA and AMPA/kainate receptors in the dorsal raphe nucleus prevents the 5-HT3 receptor agonist m-chlorophenylbiguanide-induced suppression of REM sleep in the rat

Article ID	Journal	Published Year	Pages	File Type
5845119	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2011	8 Pages	PDF

Abstract

âº Infusion of a 5-HT3 agonist into the the dorsal raphe nucleus suppresses REM sleep. âº Infusion of ionotropic glutamate antagonists into the dorsal raphe augments sleep. âº Glutamate antagonists prevent the 5-HT3 agonist-induced suppression of REM sleep.

Keywords

ICS-205,930 5-HT m-chlorophenylbiguanide m-CPBG AMPA VLPO REMS α-amino-3-hydroxy-5-methyl-4-isoxazole propionate SWS DNQX AP-5 DRN NMDA N-methyl-d-aspartate 5-HT3 receptor 5-hydroxytryptamine or serotonin 6-Cyano-7-nitroquinoxaline-2,3-dione 6,7-dinitroquinoxaline-2,3-dione NMDA receptor Electroencephalogram EMG electromyogram Wakefulness analysis of variance ANOVA Rapid-eye-movement sleep REM sleep slow wave sleep Serotonin CNQX ventrolateral preoptic area Rat EEG dorsal raphe nucleus Raphe nucleus Glu glutamate AMPA/kainate receptor