| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845125 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 | 5 Pages |
Abstract
âºCyclooxygenases (COX) and 5-lipoxygenase (5-LOX) are considered inflammatory enzymes. âºCOXs and 5-LOX appear to participate in the pathobiology of Alzheimer's disease (AD). âºTheir role in AD may involve both inflammatory and inflammation-unrelated mechanisms. âºThese mechanisms include the cell-specific brain localization of COXs and 5-LOX. âºAlso involved could be a specific interplay between the COXs and 5-LOX pathways.
Keywords
NSAIDSCOXsPGH2NSCCysLT1SNPsLXA4LTB45-LOXGPCRsPGE2PPAR5-LipoxygenaseG protein-coupled receptorsAlzheimercyclooxygenaseArachidonic acidAlzheimer's diseasePositron emission tomographyNonsteroidal anti-inflammatory drugsCNSAgingNeural stem cellcentral nervous systemCyclooxygenasesLeukotriene B4lipoxin A4LipidPETprostaglandin E receptorProstaglandin E2Prostaglandin H2Single nucleotide polymorphismsperoxisome proliferator-activated receptor
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Authors
Hari Manev, Hu Chen, Svetlana Dzitoyeva, Radmila Manev,