| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845130 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 | 8 Pages |
Abstract
âºComplex disorders have a multifactorial origin, depending on both genetic and environmental factors. âºThe effect of environmental factors may occur through the induction of epigenetic modifications. âºAging is associated with epigenetic modulation. âºAlzheimer's and Parkinson's disease are complex disorders in which the sporadic forms are strongly associated with aging. âºEpigenetics may be the missing link to explain the late-onset forms of several neurodegenerative disorders.
Keywords
CDGELearnS-adenosylhomocysteineAβSAMHDACSAHAPPHcyEOADCBSS-adenosyl methionineamyloid-βEpigeneticsLoadAlzheimer's diseaseEarly-onset Alzheimer's diseaseLate-onset Alzheimer's diseaseParkinson's diseasesubstantia nigraNeurodegenerationEtiologycystathionine-beta-synthaseMonozygoticMolecular mechanismshomocysteinehistone deacetylaseamyloid precursor proteinSNP
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Authors
Sueli C.F. Marques, Catarina R. Oliveira, Claudia M.F. Pereira, Tiago F. Outeiro,