Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder

Article ID	Journal	Published Year	Pages	File Type
5845158	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2011	7 Pages	PDF

Abstract

âº This is the first genome-wide association study focused on blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder in children. âº There were no genome-wide statistically significant associations or amongst candidate genes associated with normal variation in blood pressure. âº Gene enrichment analyses suggested a role for genes involved in regulating vascular tone (SLC24A3, PTPRM, and KCNQ5) and involved in cardiac conduction (RYR2, RYR3, SCN5A, SCN10 and KCNQ1).

Keywords

PTPRD VNTR FERM NRG1 PTMA FGFR1 Mark2 KCNQ1 SCN10A Ptprj DSM-IV-TR MYBPC3 Obscurin EDAR ectodysplasin A receptor LRP1b RYR3 Fibroblast growth factor 14 MYLK SCN5A RyR2 MTS LSAMP MAF FGF14 HWE MDS MGST1 Attention-Deficit/Hyperactivity Disorder standard deviation bpm Numb ADHD Hardy–Weinberg equilibrium variable number tandem repeat CNS DAVID myosin light chain kinase EASE central nervous system body mass index BMI beats per minute pharmacogenomic minor allele frequency Blood pressure Methylphenidate MALL Genome-wide association study GWAS multi-dimensional scaling UTR یا untranslated regions untranslated region neuregulin 1 database for annotation, visualization and integrated discovery Limbic system-associated membrane protein Single nucleotide polymorphism SNP Fibroblast growth factor receptor 1 calcitonin receptor