| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845245 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 | 10 Pages |
Abstract
⺠The mechanisms of anxiolytic action of SSRIs are unclear. ⺠SSRI inhibits conditioned freezing, an index of conditioned fear. ⺠Microinjection studies revealed the basolateral amygdala as the target of SSRIs. ⺠The facilitation of 5-HT neurotransmission ameliorates fear/anxiety.
Keywords
5-HTSNRIOCDMAOI5-hydroxytryptamineGADITCTCAAmygdalapost-traumatic stress disorderPTSDSocial anxiety disordergeneralized anxiety disorderPanic disorderObsessive–compulsive disorderConditioned freezingTricyclic antidepressantSerotonin (5-HT)SADSelective serotonin reuptake inhibitormonoamine oxidase inhibitorSSRInoradrenalineHippocampus
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Authors
Takeshi Inoue, Yuji Kitaichi, Tsukasa Koyama,