| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845262 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 | 7 Pages |
Abstract
⺠Uncertainties exist concerning the effects of antipsychotics on human adipose tissue. ⺠We used antipsychotic drugs with different propensities to induce body weight gain. ⺠Clozapine and olanzapine did not exert direct effects on human adipose tissue in vitro. ⺠Haloperidol clearly inhibited the lipogenic capacity of human mature adipocytes in vitro. ⺠We suggest a novel mechanism contributing to haloperidol lower weight gain liability.
Keywords
GAPDHLPLsdhAPBSFGAHMBSADSCsSGAHPRT1DDX58Cy5PPARγ2succinate dehydrogenase complex subunit ANonidet P-40FITCIBMXXTTNP-40FBSDMEMMature adipocytes3-isobutyl-1-methylxanthinec/ebpβCCAAT/enhancer-binding protein βDMSODulbecco's modified Eagle's mediumcycle thresholdMetabolic abnormalitiesWeight gainstandard deviationHuman adipose tissuetriglycerideAntipsychoticsDimethyl sulfoxidefetal bovine serumhuman adipose-derived stem cellscyanine 5body mass indexBMInormalization factorphycoerythrinfluorescein isothiocyanateLipoprotein lipasePhosphate-buffered salineFirst-generation antipsychoticsSecond generation antipsychoticshydroxymethylbilane synthaseHypoxanthine phosphoribosyltransferase 1optical densityglyceraldehyde 3-phosphate dehydrogenase
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Authors
Andréa L. Sertié, Angela May Suzuki, Rogério A.L. Sertié, Sandra Andreotti, Fábio B. Lima, Maria Rita Passos-Bueno, Wagner F. Gattaz,