| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845278 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 | 5 Pages |
Abstract
⺠Cyclosporine A (CsA), an calcineurin inhibitor, induces hyperlipidemia. ⺠AMP-activated protein kinase (AMPK) is involved in lipid metabolism. ⺠The activity of AMPK pathway in the rat hippocampus was examined after CsA treatment. ⺠CsA increased the phosphorylations of AMPK, upstream and downstream molecules. ⺠CsA affects the lipid metabolism in the rat brain through regulation of AMPK pathway.
Keywords
CaMKKβPKCMARCKSAMPKCPT1TAK1HMG-CoARPP2AAMPACCLKB1PP2B3-hydroxy-3-methylglutaryl coenzyme A reductaseAMP-activated protein kinasemyristoylated alanine-rich C kinase substrateAdenosine TriphosphateATPadenosine monophosphateacetyl coA carboxylaseCSACyclosporine APhosphorylationLipid metabolismRat brainprotein phosphatase 2AProtein phosphatase 2BProtein kinase Ccarnitine palmitoyl transferase 1
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Authors
Hong Geun Park, Heesun Yi, Se Hyun Kim, Hyun Sook Yu, Yong Min Ahn, Young Han Lee, Myoung-Sun Roh, Yong Sik Kim,