Mechanisms of antidepressant action: An integrated dopaminergic perspective

Article ID	Journal	Published Year	Pages	File Type
5845302	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2011	12 Pages	PDF

Abstract

âº The molecular mechanisms that cause and maintein depression are currently unknown. âº We examine some of the paradigms that are used to explain the disorder. âº We analyze these theories from the perspective of the dopaminergic system. âº Several shared components are highlighted through this perspective.

Keywords

GDNF dopamine/dopaminergic first generation antipsychotic WWT second generation antipsychotic Hdac5 serotonin receptor 1A FGA 5-HT1A GSK3 5-HIAA 5-HT NGF SGA MDD 5-Hydroxyindoleacetic acid BDNF ECs Major depressive disorder inflammation interferon α Wingless Parkinson's disease electroconvulsive seizures Antidepressant treatment Dopamine Serotonin nerve growth factor Glial cell line-derived neurotrophic factor Brain-derived neurotrophic factor Cerebrospinal fluid CSF Hypothalamus-pituitary-adrenal axis Selective serotonin reuptake inhibitor SSRI HPA noradrenaline Neurotrophin glycogen synthase kinase 3 glucocorticoid receptor