Genome-wide association studies of antidepressant outcome: A brief review

Article ID	Journal	Published Year	Pages	File Type
5845304	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2011	5 Pages	PDF

Abstract

âº Three genome-wide studies of antidepressant treatment response have been published. âº None of these studies reported results that achieved genome-wide significance. âº Rare genotypes, epigenetic changes, and other kinds of genetic variation may have a role in antidepressant response. âº Future GWAS should include larger samples and better outcome definitions.

Keywords

IL11 QIDS-SR SCL-90-R DSM-IV-TR HTR2A SLC6A4 GENDEP HAM-A MADRS BDI HAM-D MDD CDH17 UST Cadherin-17 LPR BMP7 EPHB1 ICD-10 STAR*D Major depressive disorder Genome-wide association interleukin-11 Sequenced Treatment Alternatives to Relieve Depression RORA serotonin transporter Mars Pharmacogenetics Pharmacogenomics Symptom Checklist-90-Revised Genome-wide association studies GWAS Montgomery–Åsberg Depression Rating Scale Hamilton anxiety rating scale Hamilton Depression Rating Scale BDI, Beck Depression Inventory Bone morphogenic protein 7 Single nucleotide polymorphism SNP serotonin 2A receptor