| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845386 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 | 9 Pages |
Abstract
⺠Curcumin inhibited glutamate release from rat prefrontocortical synaptosomes. ⺠A decrease in the Ca2+ influx through Cav2.2 and Cav2.1 channels was involved. ⺠Curcumin-mediated inhibition of glutamate release was occluded by fluoxetine. ⺠This study provided further understanding of the mode of curcumin action in the brain.
Keywords
VDCCHEPES buffer mediumGDHHBM4-APFura-2-AM4-aminopyridineBSADiSC3(5)dl-TBOA[Ca2+]cω-conotoxin MVIICbovine serum albuminDepressionglutamate releaseCNScentral nervous systemSynaptosomescytosolic free Ca2+ concentrationFura-2-acetoxymethyl esterprefrontal cortexVoltage-dependent Ca2+ channelCurcuminglutamate dehydrogenase
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Authors
Tzu Yu Lin, Cheng Wei Lu, Chia-Chuan Wang, Ying-Chou Wang, Su-Jane Wang,