| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845405 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2012 | 7 Pages |
Abstract
⺠We compare toxicity of haloperidol, risperidone and paliperidone in cell culture. ⺠We measured viabilility, apoptosis (fluorimetry) and cell death (flow cytometry). ⺠Haloperidol is the most neurotoxic antipsychotic and clearly induces apoptosis. ⺠Paliperidone shows the strongest neuroprotective effect and a reduced apoptosis level. ⺠Effects observed on cell survival can be related to antipsychotic-induced EPS.
Keywords
5-HTDRD2second-generation antipsychoticN-methyl d-aspartatefirst-generation antipsychoticFGARGS2Ac-DEVD-choNMDANGFCa2+/CaMpKaSGAAmC5-hydroxytryptamineFITCPBSFBSEPSERK7-amino-4-methyl-coumarinBDNFDMSOPI3K-Aktminimum essential mediumAntipsychoticDopamineTardive dyskinesiaDimethyl sulfoxidefetal bovine serumNeurotoxicityExtrapyramidal symptomsnerve growth factorBrain-derived neurotrophic factorPhosphate buffered salinePhosphatidylserinefluorescein isothiocyanateMEMNeuroprotectionNeuroblastomaprotein kinase APropidium iodideextracellular signal-regulated kinasedopamine D2 receptor
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Authors
Patricia Gassó, Sergi Mas, Oriol Molina, Miquel Bernardo, Amalia Lafuente, Eduard Parellada,