Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5845406 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2012 | 7 Pages |
Intra-cerebral administrations of folic acid produce antidepressant-like effects; either alone or combined with several antidepressant drugs. However, the specific limbic structures implied in the antidepressant-like actions of folic acid are un-known. Thus, intra-lateral septal infusions of folic acid (5.0Â nmol, PÂ <Â 0.05; 10.0Â nmol, PÂ <Â 0.05) or oral administrations of folic acid (50Â mg/kg, PÂ <Â 0.05, p.o.; 75.0; mg/kg, PÂ <Â 0.05, p.o.) or systemic administrations of fluoxetine (20.0Â mg/kg, PÂ <Â 0.05; 25.0Â mg/kg, PÂ <Â 0.05) reduced immobility by increasing swimming behavior in the forced swimming test (FST) of male Wistar rats. Conversely, desipramine (10.0Â mg/kg, PÂ <Â 0.05; 15.0Â mg/kg, PÂ <Â 0.05) reduced immobility by increasing climbing behavior. Subthreshold doses of folic acid (2.5Â nmol/intra-LSN) combined with subthreshold doses of folic acid (25.0Â mg/kg, p.o., PÂ <Â 0.05) or with subthreshold doses of fluoxetine (15.0Â mg/kg, PÂ <Â 0.05) and they produced antidepressant-like effects which were canceled by ketanserin. In conclusion, intra-lateral septal infusions of folic acid alone or combined with systemic doses of folic acid or fluoxetine reduced immobility in the FST. These antidepressant-like actions, probably, were due to modifications of the serotonergic system since swimming behavior was increased and these effects were canceled by ketanserin.
⺠Folic Acid (Intra-LSN) produced antidepressant-like actions. ⺠Folic Acid (Intra-LSN) plus fluoxetine produced antidepressant-like actions. ⺠Ketanserin canceled the antidepressant-like actions of antidepressant drugs. ⺠Ketanserin canceled the antidepressant-like actions of folic acid. ⺠Intra-lateral septal infusions of folic acid produced antidepressant effects.