| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845456 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 | 6 Pages |
Abstract
⺠The chronic use of biperiden may decrease cognitive function in schizophrenia. ⺠Biperiden can be discontinued by gradual dose reduction without adverse effects. ⺠Biperiden reduction at a rate of 1 mg/2-4 weeks is a safe discontinuation strategy. ⺠Discontinuing biperiden use can improve attention and processing speed. ⺠Discontinuing biperiden use can improve subjective QOL and psychiatric symptoms.
Keywords
DIEPSSEPSSPSSSGAsQOLPANSSFGAsDSM-IV-TRCGI-SQuality of lifeSchizophreniastandard deviationstatistical package for social sciencesbiperidenanalysis of varianceANOVADiagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text RevisionExtrapyramidal symptomsCognitive functionpositive and negative syndrome scaleFirst-generation antipsychoticsSecond-generation antipsychotics
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Authors
Shin Ogino, Seiya Miyamoto, Tomomi Tenjin, Rei Kitajima, Kazuaki Ojima, Nobumi Miyake, Yasuyuki Funamoto, Jun Arai, Sachiko Tsukahara, Yukie Ito, Masanori Tadokoro, Kiriko Anai, Shinobu Tatsunami, Hiroshi Kubota, Yasuhiro Kaneda, Noboru Yamaguchi,