Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in mild and moderate depression

Article ID	Journal	Published Year	Pages	File Type
5845468	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2011	8 Pages	PDF

Abstract

âº Oxytocin (OT) and vasopressin (VP) autoantibodies are low in moderate depression. âº OT and VP autoantibody levels correlate with depression scale. âº VP autoantibody levels correlate with plasma cortisol. âº Blunted response of plasma cortisol to physical exercise in moderate depression. âº Relevance of OT and VP autoantibodies to stress axis activity and depression.

Keywords

ACTH EDI autoantibodies TSA CRH DSM α-MSH MADRS BIA mood disorders Stress standard deviation oxytocin Natural immunity immunoglobulin third ventricle biospecific interaction analysis ELISA Enzyme-linked immunosorbent assay Tyramide Signal Amplification standard error Room temperature Diagnostic and Statistical Manual of Mental Disorders Behavior body mass index BMI SON PVN CSF Cerebrospinal fluid HPA Neuropeptides Supraoptic nucleus paraventricular nucleus adrenocorticotropic hormone corticotropin-releasing hormone α-melanocyte-stimulating hormone hypothalamo-pituitary-adrenal vasopressin optical density optic chiasm