NTM and NR3C2 polymorphisms influencing intelligence: Family-based association studies

Article ID	Journal	Published Year	Pages	File Type
5845480	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2011	7 Pages	PDF

Abstract

âºFamily-based association designs can avoid the potential confounding effects of population stratification. âºIdentified two novel genes (NTM and NR3C2) associated with IQ. âºTwo loci are well-replicated in an independent sample. âºHaplotype analyses further supported the associations in single-maker analysis.

Keywords

Collaborative Study on the Genetics of Alcoholism NR3C2 SLC5A8 CHRM2 Neurotrimin COGA FBAT GWA NIAAA WAIS-R NTM ELMO1 COMT FSIQ MAF EMP HWE CTSD Family-based association test Attention-Deficit/Hyperactivity Disorder Genome-wide association intelligence quotient ADHD Image Hardy–Weinberg equilibrium Linkage disequilibrium minor allele frequency Wechsler Adult Intelligence Scale-Revised National Institute on Alcohol Abuse and Alcoholism HPA hypothalamic–pituitary–adrenal Single-nucleotide polymorphism Single-nucleotide polymorphisms SNP cathepsin D catechol-o-methyl transferase GAW Mineralocorticoid receptor glucocorticoid receptor