| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845490 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 | 14 Pages |
Abstract
⺠We evaluated molecular mechanisms of antipsychotics plus valproate combination. ⺠Antipsychotic plus valproate impact on Homer1a is different from individual effect. ⺠Our data confirm Homer1a region-specific modulation by antipsychotics. ⺠Homer1a expression is correlated with the degree of dopamine D2 receptors blockade. ⺠Homer1a is modulated in the cortex by dopamine and serotonin neurotransmission.
Keywords
AcCoNMDARmGluRsIEGscPVLCPDMN-methyl-D-aspartate glutamate receptorERKSSCPSDGSK3BHomer1aCPDLPBSROIsbipolar disorderanalysis of varianceANOVApostsynaptic densityDopamineValproatePhosphate buffered salineMotor cortexinsular cortexSomatosensory cortexanterior cingulate cortexRegions Of Interestnucleus accumbens corenucleus accumbens shellImmediate-early genesQuetiapineextracellular signal-regulated kinaseglycogen synthase kinase 3 betaMetabotropic glutamate receptors
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Authors
Carmine Tomasetti, Carmela Dell'Aversano, Felice Iasevoli, Federica Marmo, Andrea de Bartolomeis,