| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5845908 | Toxicology and Applied Pharmacology | 2015 | 9 Pages |
Abstract
These data demonstrated that the up-regulation of pulmonary fibroblast-derived MCP-1 is involved in pulmonary fibroblast migration induced by SiO2. CCR2 was also up-regulated in response to SiO2, and this up-regulation facilitated the effect of MCP-1 on fibroblasts. Our study deciphered the link between fibroblast-derived MCP-1 and SiO2-induced cell migration. This finding provides novel insight into the potential of MCP-1 in the development of novel therapeutic strategies for silicosis.
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Authors
Xueting Liu, Shencun Fang, Haijun Liu, Xingang Wang, Xiaoniu Dai, Qing Yin, Tianwei Yun, Wei Wang, Yingming Zhang, Hong Liao, Wei Zhang, Honghong Yao, Jie Chao,