| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846436 | Toxicology and Applied Pharmacology | 2013 | 10 Pages |
Abstract
⺠BDCM acute exposure sensitizes liver to increased free radical stress in obesity. ⺠BDCM-induced higher leptin contributes to early steatohepatitic lesions. ⺠Increased leptin mediates protein radical and 3-nitrotyrosine formation. ⺠BDCM exposure in obesity activates Kupffer cells and NADPH oxidase. ⺠BDCM/leptin synergy promotes necrotic cell-death and augments steatohepatitis.
Keywords
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Suvarthi Das, Ashutosh Kumar, Ratanesh Kumar Seth, Erik J. Tokar, Maria B. Kadiiska, Michael P. Waalkes, Ronald P. Mason, Saurabh Chatterjee,