| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846589 | Toxicology and Applied Pharmacology | 2012 | 8 Pages |
Abstract
⺠Atrazine stimulates cAMP accumulation in pituitary and Leydig cells. ⺠Atrazine also stimulates PRL and androgens secretion. ⺠Stimulatory effects of atrazine were abolished in cells with IBMX-inhibited PDEs. ⺠Atrazine specificity toward cAMP-specific PDEs was indicated by no changes in cGMP. ⺠Rolipram, a specific PDE4 inhibitor, also prevents stimulatory effects of atrazine. ⺠Atrazine acts as an endocrine disrupter by inhibiting cAMP-specific PDE4.
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Authors
Marek Kucka, Kristina Pogrmic-Majkic, Svetlana Fa, Stanko S. Stojilkovic, Radmila Kovacevic,