Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells

Article ID	Journal	Published Year	Pages	File Type
5846598	Toxicology and Applied Pharmacology	2012	10 Pages	PDF

Abstract

âº Isoorientin induced apoptosis in HepG2 cells. âº Isoorientin disordered mitochondrial function and inhibited PI3K/AKt pathway. âº PI3K/Akt pathway mediated mitochondrial dysfunction via Bcl-2 family members. âº Isoorientin stimulated the intracellular ROS and NO generation in HepG2 cells. âº ROS and NO initiated mitochondria dysfunction and involved in PI3K/Akt pathway.

Keywords

MMP N-acetylcystein NAC Isoorientin PARP MPTP 1400W PI3K/AKT ROS mitochondrial stress mitochondrial permeability transition pore Apoptosis HepG2 cells Nitric oxide Mitochondrial membrane potential poly (ADP-ribose) polymerase Reactive oxygen species