| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846627 | Toxicology and Applied Pharmacology | 2013 | 11 Pages |
Abstract
⺠We used metabolomics to gain insights on drug induced liver injury (DILI) in rats. ⺠We profiled rats treated with thirteen hepatotoxins at two doses and two time points. ⺠The toxins decreased the liver's ability to uptake bile acid from the circulation. ⺠Oxidative stress induced by the toxins altered bile acid biosynthesis in the liver. ⺠Selected bile acids in the plasma and urine could be sensitive DILI biomarkers.
Keywords
GGT1-naphthylisothiocyanateGLDHTBILANITsorbitol dehydrogenaseETNMTPBDZAPAPCCl4ALTTTCCbzNMSSDHFtMASTAspartate aminotransferaseDrug-induced liver injuryAlanine aminotransferaseALPAlkaline phosphataseAcetaminophenCSABiomarkerTetracyclineOxidative stressTiclopidineDILIHepatotoxicityCyclosporine AflutamideTCPMetabolomicsMethapyrileneMechanism of actionNimesulidecarbamazepineCarbon tetrachloridetotal bilirubinGamma-glutamyl transferaseglutamate dehydrogenase
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Makoto Yamazaki, Manami Miyake, Hiroko Sato, Naoya Masutomi, Naohisa Tsutsui, Klaus-Peter Adam, Danny C. Alexander, Kay A. Lawton, Michael V. Milburn, John A. Ryals, Jacob E. Wulff, Lining Guo,