| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846699 | Toxicology and Applied Pharmacology | 2012 | 9 Pages |
Abstract
⺠Glucuronidation is the main reason for the poor oral bioavailability of emodin. ⺠Efflux transporters are involved in the excretion of emodin glucuronide. ⺠The intestine is the main organ for metabolism of emodin.
Keywords
NTPbasolateralUDPGALTC4TEERBcrpMRPHBSSUPLCDMEMAICUGTDulbecco's modified Eagle's mediumUDP-glucuronosyltransferasesUDP-glucuronosyltransferaseSprague–Dawleyuridine diphosphoglucuronic acidEmodinApicalNational Toxicology ProgramCaco-2 cellsLeukotriene C4Hank's balanced salt solutionAkaike's Information Criteriontransepithelial electrical resistanceIntrinsic clearancemultidrug resistance-associated proteinbreast cancer resistance proteinmultidrug resistance-associated proteins
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Authors
Wei Liu, Qian Feng, Ye Li, Ling Ye, Ming Hu, Zhongqiu Liu,