| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846704 | Toxicology and Applied Pharmacology | 2012 | 8 Pages |
Abstract
⺠NAD(P)H:quinone oxidoreductase expression in Cyp1a knockout and humanized CYP1A mice ⺠Reductive activation of the nephrotoxic and carcinogenic aristolochic acid I (AAI) ⺠NAD(P)H:quinone oxidoreductase is induced in mice treated with AAI. ⺠Induced hepatic enzyme activity resulted in elevated AAI-DNA adduct levels.
Keywords
Nrf2BENDNA adductsNQO1AAIPORHRNXRETLCCyPP450 oxidoreductaseSDSAHRUUCrelative adduct labelingaristolochic acid Ikeap1NAD(P)H:quinone oxidoreductaseNATsAANROSAristolochic acidProtein expressionRALsodium dodecyl sulfateSulfotransferasesCytochrome P450Metabolic activationMouse modelsaristolochic acid nephropathyBalkan endemic nephropathywild-typeAREUpper urinary tract urothelial carcinomathin-layer chromatographySULTsReactive oxygen speciesaryl hydrocarbon receptor
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Katerina Levova, Michaela Moserova, Daniel W. Nebert, David H. Phillips, Eva Frei, Heinz H. Schmeiser, Volker M. Arlt, Marie Stiborova,