Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/Î²-catenin signaling pathway

Article ID	Journal	Published Year	Pages	File Type
5846711	Toxicology and Applied Pharmacology	2012	11 Pages	PDF

Abstract

âº Carcinogenic metals in drinking water promote colorectal tumor formation in vivo. âº Carcinogenic metals induce Î²-catenin activation in vivo and in vitro. âº ROS generation induced by carcinogenic metals mediated Î²-catenin activation.

Keywords

NOX1 DMEM FBS azoxymethane NTP SDD IEF DSS 8-OHdG AOM 8-hydroxydeoxyguanosine H&E Dulbecco's modified Eagle's medium MTT NADPH oxidase 1 ROS IARC یا International Agency for Research on Cancer International Agency for Research on Cancer SDS-PAGE SDS polyacrylamide gel electrophoresis National Toxicology Program isoelectric focusing fetal bovine serum dextran sodium sulfate Hematoxylin & Eosin Cr(VI)Hexavalent chromium Reactive oxygen species

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

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Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/Î²-catenin signaling pathway

Authors

Xin Wang, Ardhendu K. Mandal, Hiroshi Saito, Joseph F. Pulliam, Eun Y. Lee, Zun-Ji Ke, Jian Lu, Songze Ding, Li Li, Brent J. Shelton, Thomas Tucker, B. Mark Evers, Zhuo Zhang, Xianglin Shi,