Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet

Article ID	Journal	Published Year	Pages	File Type
5846715	Toxicology and Applied Pharmacology	2012	8 Pages	PDF

Abstract

âº Choline- and folate-deficiency induces a strain-specific fatty liver injury in mice. âº The extent of liver pathology was accompanied by the changes in microRNA expression. âº The levels of circulating microRNAs mirror the magnitude of fatty liver injury. âº Plasma microRNAs may be sensitive noninvasive indicators of the fatty liver injury.

Keywords

miRNAs qRT-PCR ALT NAFLD AST Aspartate aminotransferase Alanine aminotransferase nonalcoholic steatohepatitis Nonalcoholic fatty liver disease Inter-individual differences microRNAs lactate dehydrogenase LDH Mouse Nash

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

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Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet

Authors

Volodymyr P. Tryndyak, John R. Latendresse, Beverly Montgomery, Sharon A. Ross, Frederick A. Beland, Ivan Rusyn, Igor P. Pogribny,