| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846733 | Toxicology and Applied Pharmacology | 2012 | 10 Pages |
Abstract
⺠STK regulates alternative macrophage activation after acetaminophen intoxication. ⺠Loss of STK results in increased sensitivity to acetaminophen. ⺠Increased toxicity involves oxidative stress and decreases in repair macrophages.
Keywords
STKHeme oxygenase-1ALTiNOSHO-1GAPDHGSHMCP-1CyPNAPQIMIPTNFαPBSTNFRASTalanine transaminaseAcetaminopheninflammationinterleukinaspartate transaminasetumor necrosis factor-αinducible nitric oxide synthaseCytochrome P450CytokinesMacrophagesPhosphate-buffered salinemacrophage inflammatory proteinmonocyte chemoattractant protein-1LiverGlutathioneglyceraldehyde 3-phosphate dehydrogenasetumor necrosis factor receptor
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Authors
Carol R. Gardner, Pamela Hankey, Vladimir Mishin, Mary Francis, Shan Yu, Jeffrey D. Laskin, Debra L. Laskin,