| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846736 | Toxicology and Applied Pharmacology | 2012 | 10 Pages |
Abstract
⺠In contrast to rats, male mice are more sensitive to TCDD toxicity than female mice. ⺠The resistance of female C57BL/6Kuo mice matches or exceeds that of male DBA/2 mice. ⺠The resistance of female C57BL/6Kuo mice is not based on AHR structure or abundance. ⺠Both androgens and estrogens appear to influence TCDD sensitivity. ⺠TCDD sensitivity correlates best with the severity of lesions in the liver.
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Authors
Raimo Pohjanvirta, Hanna Miettinen, Satu Sankari, Nagabhooshan Hegde, Jere Lindén,