| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846745 | Toxicology and Applied Pharmacology | 2012 | 8 Pages |
Abstract
⺠Chronic exposure to cadmium induces carcinogenic properties in BEAS-2B cells. ⺠ROS involved in cadmium-induced tumorigenicity of BEAS-2B cells. ⺠Cadmium activates ROS-dependent AKT/GSK-3β/β-catenin-mediated signaling. ⺠ROS-dependent signaling as potential therapeutic targets in cadmium carcinogenesis.
Keywords
MmpsCATGSHCOX-2APCGSK-3βHIF-1αFBSDMEMIACUCO2•-Dulbecco's modified Eagle's mediumROSHydrogen peroxideadenomatous polyposis colisuperoxide anionβ-cateninHydroxyl radicalsSODCarcinogenesisfetal bovine serumSuperoxide dismutaseCyclooxygenase-2hypoxia-inducible factor-1αVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)matrix metalloproteinaseNitric oxideH2O2CatalaseCadmiumGlutathioneGlycogen synthase kinase-3βReactive oxygen species•OH
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Authors
Young-Ok Son, Lei Wang, Pratheeshkumar Poyil, Amit Budhraja, J. Andrew Hitron, Zhuo Zhang, Jeong-Chae Lee, Xianglin Shi,