| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846747 | Toxicology and Applied Pharmacology | 2012 | 15 Pages |
Abstract
⺠mtDNA SNPs may be linked to individual predisposition to drug-induced toxicity. ⺠CZECHII/EiJ and PERA/EiJ mtDNA was sequenced for the first time in this study. ⺠Strain-dependent mitochondrial capacity differences were measured. ⺠Strain-dependent differences in response to mitochondrial toxicants were observed.
Keywords
DTNBrRNAtRNAOCRLHONMEFs2-deoxy-d-glucoseFCCPnDNASNPs2-DGBSADMSOMitochondrial DNANuclear DNAAdenosine TriphosphateATPbovine serum albuminribosomal ribonucleic acidtransfer ribonucleic acidmtDNADimethyl sulfoxideBioenergeticsDrug-induced toxicitymouse embryonic fibroblastsMitochondriaOxygen consumption rateNADHLeber hereditary optic neuropathySingle nucleotide polymorphismsreduced nicotinamide adenine dinucleotidecarbonyl cyanide-p-trifluoromethoxyphenylhydrazone
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Authors
Claudia V. Pereira, Paulo J. Oliveira, Yvonne Will, Sashi Nadanaciva,