| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846752 | Toxicology and Applied Pharmacology | 2012 | 10 Pages |
Abstract
⺠Nanobody therapy prevents the hemodynamic disturbances induced by a lethal dose. ⺠Late injection of Nanobody restores hemodynamic parameters to baseline values. ⺠Nanobody therapy prevents lung and heart lesions of treated mice after envenoming. ⺠Labeled Nanobody and Fab'2 pharmacokinetics curves reach plateau in favour of Nanobody.
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Authors
Issam Hmila, Bernard Cosyns, Hayfa Tounsi, Bram Roosens, Vicky Caveliers, Rahma Ben Abderrazek, Samir Boubaker, Serge Muyldermans, Mohamed El Ayeb, Balkiss Bouhaouala-Zahar, Tony Lahoutte,