| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846768 | Toxicology and Applied Pharmacology | 2012 | 14 Pages |
Abstract
⺠Mouse small intestine gene expression is highly responsive to hexavalent chromium [Cr(VI)]. ⺠Cr(VI) elicits more differential gene expression after 7 days of exposure than 90 days of exposure. ⺠Oral exposure to Cr(VI) leads to oxidative stress, cell cycle, lipid and immune dysregulation. ⺠Cr(VI) elicits dose-dependent changes in gene expression with an overall median EC50 of 47 mg/L SDD.
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Authors
Anna K. Kopec, Suntae Kim, Agnes L. Forgacs, Timothy R. Zacharewski, Deborah M. Proctor, Mark A. Harris, Laurie C. Haws, Chad M. Thompson,