| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846775 | Toxicology and Applied Pharmacology | 2012 | 13 Pages |
Abstract
⺠Intratracheal instillation of W-Ni-Co and W-Ni-Fe induces lung inflammation in rats. ⺠W-Ni-Co and W-Ni-Fe alter expression of oxidative stress and toxicity genes. ⺠W-Ni-Co induces a greater oxidative burst response than W-Ni-Fe in lung macrophages.
Keywords
HMTA2′,7′-dichlorodihydrofluorescin diacetateCDKN1ABALRNSDCFH-DADcf2′,7′-dichlorodihydrofluoresceinROSTungsten alloyinflammationDepleted UraniuminterleukinGene expressiontumor necrosis factor alphaPulmonary toxicitycytokine-induced neutrophil chemoattractantTNF-αbronchoalveolar lavagelactate dehydrogenaseLDHcyclin-dependent kinase inhibitor 1AOxidative burstCINCreactive nitrogen speciesReactive oxygen species
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Authors
Erik Q. Roedel, Danielle E. Cafasso, Karen W.M. Lee, Lisa M. Pierce,