| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846801 | Toxicology and Applied Pharmacology | 2012 | 10 Pages |
Abstract
⺠Time course study on nanoceria induced hepatic alterations in rats. ⺠Serum AST elevation indicated acute hepatotoxicity. ⺠Ceria is retained for up to 30 days in Kupffer cells, stellate cells and hepatocytes. ⺠Biopersistence of nanoceria induced hepatic granuloma formation. ⺠Chronic presence of nanoceria elevated hepatic protein carbonyl levels.
Keywords
DLSPCNAENMEDSMnSODMDLHspHR-TEMEELSGPXHydrogen peroxideASTAspartate aminotransferaseProliferating Cell Nuclear AntigenImmunohistochemistryIHCBiodistributionTUNELStemKupffer cellmanganese superoxide dismutaseCeriaBETElectron energy loss spectroscopyICP-MSinductively coupled plasma mass spectrometryMethod Detection LimitEngineered nanomaterialElectron microscopyHigh Resolution Transmission Electron MicroscopySTEM, scanning transmission electron microscopyH2O2Heat shock proteinProtein carbonylsLiverGranulomaglutathione reductaseglutathione peroxidaseCerium ion
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Authors
Michael T. Tseng, Xiaoqin Lu, Xiaoxian Duan, Sarita S. Hardas, Rukhsana Sultana, Peng Wu, Jason M. Unrine, Uschi Graham, D. Allan Butterfield, Eric A. Grulke, Robert A. Yokel,