| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846819 | Toxicology and Applied Pharmacology | 2011 | 11 Pages |
Abstract
⺠We expressed rat Nav1.6 voltage-gated sodium channels in HEK293 cells. ⺠Tefluthrin and deltamethrin caused resting modification of Nav1.6 channels. ⺠Only deltamethrin exhibited use-dependent enhancement of modification. ⺠State-dependent effects of pyrethroids are influenced by the cellular context. ⺠Channels in HEK293 cells exhibit properties similar to native neuronal channels.
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Authors
Bingjun He, David M. Soderlund,