Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5846836 | Toxicology and Applied Pharmacology | 2011 | 10 Pages |
Abstract
⺠During acetaminophen overdose caspase-3 can be activated in fed mice of certain outbred strains. ⺠Hepatic ATP levels are not the determining factor for caspase activity. ⺠Caspase-3 activity does not result in increased hepatocellular apoptotic cell death. ⺠Neutrophil recruitment during acetaminophen occurs independently of nutritional status. ⺠Fed or fasted state does not alter the mechanisms of acetaminophen-induced cell death.
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Authors
C. David Williams, Michael R. Koerner, Jed N. Lampe, Anwar Farhood, Hartmut Jaeschke,